Sesquiterpenes and other constituents from Dendranthema zawadskii var. latilobum.

نویسندگان

  • Hyun Jung Shin
  • So Young Lee
  • Ju Sun Kim
  • Sanghyun Lee
  • Ran Joo Choi
  • Ha Sook Chung
  • Yeong Shik Kim
  • Sam Sik Kang
چکیده

Six new germacranolides, zawadskinolides A-F (1-6), and a new eudesmane glucoside, chrysantiloboside (7) were isolated from the aerial parts of Dendranthema zawadskii var. latilobum, along with thirteen known constituents. Their structures were elucidated by means of spectroscopic evidence. Bioassay showed that flavonoids such as apigenin (9), (-)-eriodictyol (10) and nepetin (12), as well as the sesquiterpene lactone, zawadskinolide F (6), inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC50 values of 66.15, 132.55, 35.44, and 91.32 μM, respectively.

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عنوان ژورنال:
  • Chemical & pharmaceutical bulletin

دوره 60 3  شماره 

صفحات  -

تاریخ انتشار 2012